Some caveats, though: To share the same home folder safely, it’s best to use the same desktop environment on both distros. Debian paired with Fedora makes it difficult to match the release numbers of the desktops, though, and there might be discrepancies with respect to user config files in the home folder, when you’re trying to configure features in Fedora that aren’t yet available in Debian.
Also the system folder setup (locations of libraries and include files) is different between the two, so if there’s anything in the home folder that’s linked against libraries in one distro, it won’t work in the other. Especially if you’re going to compile anything in the home folder – including stuff that package managers of scripting languages like lua and python themselves compile – that could lead to major heaadaches.
This is the right response to the OP’s bizarre “question”, of course, but … yeah … the ‘for the most part’ qualifier is key here.