Roll20 stats one year showed primarily 5e, but that’s also what it works best with (in my opinion), and I think general sentiment has changed for d&d generally. My group started with 5e, but we haven’t really played it much recently. My first group we never did d&d, though started and never finished multiple. So I don’t think so, but it’s one of the more popularized options.

Just finished a long campaign using a system loosely based on 5e based on Animorphs that my friend made. Has entirely new classes, races, feats, and abilities.