That sounds like bad data got written to some config files, because a reboot should have corrected a simple bad handoff and restored the preconfigured state. Might have been interesting to see what xrandr had to say about those monitors at the time, and whether it could have fixed them.
Anyway, sounds like your side monitors got disabled, and rather than re-enabling them when you exited WINE, something in the stack decided they’d always been that way . . . but because they were still powered and connected, the monitors still said “hi” every few minutes, and then got identified and swatted down again. I doubt I would have had the hand-speed to re-enable them through the GUI the way you did.


Heh. I’m old and my reflexes are dropping off. Plus, as a Gentoo user, I tend to reach for the command-line tools first.