I have been on Concerta for around 6 years. As I understand it, Concerta does not have a cross tolerance with Adderall or Vyvanse, but both do with Concerta… so if I need to switch from Concerta it should be an open option.
With that being said, I try and maintain a roughly stable dosage, I try and eat right and sleep right, and I don’t take my medication on the weekend or on vacation.
ADHD and depression are super, super comorbid though.