On NVIDIA it works pretty much seamlessly, though there might be some caveats with vkd3d games. It (nvapi) is now enabled by default in Proton/Wine I think? (someone please correct me if not true)
On AMD it works with both radv and amdvlk drivers, though radv is still a little slower than amdvlk/the Windows driver.
That depends on the graphics driver and API: